Accession Number : ADA113089

Title :   The Synthesis and Evaluation of 15-Keto-PGB1 Analogs.

Descriptive Note : Annual technical rept. no. 2, 1 Mar 81-1 Mar 82,

Corporate Author : SAINT JOSEPH'S UNIV PHILADELPHIA PA DEPT OF CHEMISTRY

Personal Author(s) : Nelson,George L

PDF Url : ADA113089

Report Date : 01 Mar 1982

Pagination or Media Count : 24

Abstract : The initial reaction pathway for the oligomerization of 15-dehydro-PGB1 was determined by the investigation of structurally simpler analogues. This information was used to (1) provide structural insights into the complex oligomeric mixture termed PGBx, (2) develop mild reaction conditions for the conversion of 15-dehydro-PGB1 into less complicated oligomeric mixtures still retaining mitochondrial activity, and (3) design structural modifications that would result in the formation of less complicated oligomeric mixtures that still retain the unique mitochondrial protective effect. (Author)

Descriptors :   *Synthesis(Chemistry), *Test and evaluation, *Reaction kinetics, *Polymers, Phosphorylation, Mixtures, Molecular structure, Molecular weight, Modification, Mitochondria, Protection, Copolymers, Cyclopentanes, Ketones, Oxidation

Subject Categories : Polymer Chemistry
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Distribution Statement : APPROVED FOR PUBLIC RELEASE