Accession Number : ADA113229

Title :   Super Hydrides.

Descriptive Note : Final rept. 1 Feb 79-31 Jan 82,


Personal Author(s) : Brown,Herbert C

PDF Url : ADA113229

Report Date : 18 Mar 1982

Pagination or Media Count : 23

Abstract : The unusual reactivity of lithium triethylborohydride (Super Hydride) encouraged us to examine the selective reduction properties of a number of new reducing agents. Lithium trialkylborohydrides (LiR3BH) reduce most of the organic functional groups rapidly. On the other hand, lithium borohydride (LiBH4) is a mild reducing agent. In order to develop new reagents which can be used for specific reductions, the alkali metal dialkylborohydrides (MR2BH2) and alkylborohydrides (MRBH3) were prepared successfully. Although the full potentialities of these reagents are yet to be explored, preliminary studies have shown very encouraging results. We have developed new improved methods for the reduction of esters, nitriles, and amides with the convenient and readily available reagent, borane-dimethyle sulfide (BH3.SMe2, BMS). These developments have simplified the reduction of such functional groups. Lithium borohydride, a relatively expensive, but useful, reducing agent, has been prepared from sodium borohydride. This method is generally applicable for the preparation of various borohydrides.

Descriptors :   *Reaction kinetics, *Reduction(Chemistry), *Lithium compounds, *Boron hydrides, *Ethyl radicals, Alkali metals, Borohydrides, Chemicals, Sodium borohydrides, Amides, Nitriles, Esters

Subject Categories : Inorganic Chemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE