Accession Number : ADA113473

Title :   Acute Albumin-Induced Plasma Volume Expansion and Heat Exposure: Hormonal Responses in Men,


Personal Author(s) : Francesconi,R P ; Hubbard,Roger W ; Sawka,M N ; Matthew,W T ; Mager,Milton

PDF Url : ADA113473

Report Date : 08 Mar 1982

Pagination or Media Count : 25

Abstract : To determine the effects of acute plasma volume expansion and heat exposure on hormonal responses in men, two doses of albumin were administered intravenously followed by exposure to heat stress (37 C, 30-35% RH). Plasma volume was previously established by a dye dilution technique using indocyanine green. During heat exposure blood samples were taken from antecubital catheters at 1, 3, 6, 9, 12 and 24 hours following completion of albumin or saline (control) infusion, and the plasma analyzed for several hormones. No significant effects of heat stress or albumin administration were noted on circulating cortisol concentrations. Even the finely controlled diurnal/noctural periodicity of cortisol and aldosterone secretion were unaffected by heat stress or volume expansion, but there did occur a significant reduction in plasma levels of aldosterone as a result of albumin-induced plasma volume expansion. No changes were observed in circulating angiotensin I (plasma renin activity) or arginine-vasopressin (antidiuretic hormone). We concluded that the duration and intensity of heat stress used in these studies had no effects on plasma hormonal levels and periodicities, but plasma volume expansion elicited a significant decrement in aldosterone concentrations. (Author)

Descriptors :   *Heat stress(Physiology), *Blood plasma, *Hormones, *Albumins, Response(Biology), Cortisol, Aldosterone, Males, Blood volume, Level(Quantity)

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE