Accession Number : ADA114508

Title :   The Antithrombin III Content of Cryoprecipitate Prepared from Blood Collected with and without Heparin,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s) : Cosgriff,Thomas M ; Hodgson,Loreen A ; West,James V

PDF Url : ADA114508

Report Date : 08 Apr 1982

Pagination or Media Count : 14

Abstract : Antithrombin III (AT III) is a plasma protein which acts as the principal inhibitor of thrombin and is a major modulator of intravascular coagulation. Hereditary deficiency of AT III leads to recurrent episodes of thromboembolism. Acquired deficiency of AT III occurs in persons with a variety of conditions, including severe liver disease and disseminated intravascular coagulation. Replacement of At III may be important in some deficient persons. To determine if cryoprecipitate is a useful source of AT III, we measured at AT III content of cryoprecipitate prepared from citrate phosphate dextrose (CPD) blood using coagulation, fluorogenic, and immunoassays. Using the fluorogenic assay, we also determined the effect of adding heparin to blood on cryoprecipitation of AT III. Functional and antigenic AT III levels were similar to those of normal plasma in all CPD units tested, indicating that AT III is not concentrated in cryoprecipitate. Heparin had no effect on the cryoprecipitation of AT III. (Author)

Descriptors :   *Blood proteins, *Thrombin, *Blood coagulation, Inhibitors, Precipitation, Heparin, Therapy, Replacement

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE