Accession Number : ADA114974

Title :   Response of Combined Electrical Stimulation and Applied Laboratory and Clinical Studies on Biodegradable Ceramic.

Descriptive Note : Annual rept. no. 5, Jul 79-Nov 80,


Personal Author(s) : Lemons,J E

PDF Url : ADA114974

Report Date : Mar 1981

Pagination or Media Count : 24

Abstract : Investigations on granular (1, 2 or 3 mm average size) and rod (1 cm diameter x 1 cm length) form porous tricalcium phosphate ceramic has shown good biocompatibility in rabbit and dog animal models. The granular form was mixed with equal weights of autogenous bone and 8 mm tibial lesions in rabbits evaluated at 3, 6 and 9 months post surgery. Twenty three of twenty five comparable sites healed and showed no specific correlation with ceramic particulate size. Rod form ceramic implants in the mid position of dog radii showed continued biodegradation at healed and nonunion sites. Initial human clinical investigations for the granular form ceramic with autogeneous bone should initiate in 1981. (Author)

Descriptors :   *Bones, *Ceramic materials, *Biodeterioration, Surgery, Repair, Stimulation(Physiology), Electric current, Anatomical models, Laboratory animals, Dogs, Rabbits

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE