Accession Number : ADA116102

Title :   A Preliminary Report on the Osteogenic Potential of a Biodegradable Copolymer of Polylactide: Polyglycolide (PLA:PGA). Revised.

Descriptive Note : Rept. for Jul-Dec 81,


Personal Author(s) : Hollinger,Jeffrey O

PDF Url : ADA116102

Report Date : 22 Jun 1982

Pagination or Media Count : 27

Abstract : A biodegradable copolymer of 50:50 polyactide: polyglycolide was prepared for implantation into experimentally created osseous defects in the tibias of 25 rats. Similarly prepared defects were made in the humeri and these did not receive copolymer implants. At 7, 14, 21, 28, and 42 days five animals were sacrificed and the implant and untreated sites were evaluated by gross visual inspection and by histologic examination using a Zeiss Videoplan Image Analysis System with Osteoplan for the quantitation of bone morphometrics. When compared with bony defects that were not treated with the biodegradable copolymer implant, the implant sites displayed a slightly accelerated healing response rate at 7 days (p0.01), a slightly accelerated response rate of 14 and 21 days (p0.005), and a similar healing response rate of 28 and 42 days (p0.01). The copolymer was highly tissue tolerant throughout the period of the investigation. (Author)

Descriptors :   *Copolymers, *Surgical implantation, Biodeterioration, Bones, Materials

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE