Accession Number : ADA116805

Title :   Ion-Selective Electrodes for Basic Drugs.

Descriptive Note : Interim technical rept.,


Personal Author(s) : Cunningham,Larry ; Freiser,Henry

PDF Url : ADA116805

Report Date : Jan 1981

Pagination or Media Count : 22

Abstract : This paper describes the preparation and evaluation of electrodes selective to methadone, cocaine, protriptyline, and methylamphetamine. These compounds were chosen because they are protonated amines in the physiologic pH range, and are representative of some important families of pharmaceuticals: methylamphetamine (MW = 150) a central nervous system stimulant; protriptyline (MW = 263) an anti-depressant; methadone (MW = 310) a narcotic analgesic; and cocaine (MW = 303) a local anaesthetic. Coated-wire ion-selective electrodes based on dinonylnaphthalene sulfonic acid (DNNS) are prepared for methadone, methylamphetamine, cocaine, and protriptyline in protonated form. In each set, nearly Nernstian responses are obtained. Selectivity is found to decrease in the order methadone, protriptyline, cocaine, and methylamphetamine; results which are consistent with systematic selectivity studies reported earlier for electrodes in this family.

Descriptors :   *Drugs, *Electrodes, Selection, Ions, Coatings, Cations, Measurement, Cocaine, Amphetamines, Methyl radicals, Membranes, Polyvinyl chloride

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE