Accession Number : ADA116812

Title :   Distamycin Analogs as Potential Antimalarials.

Descriptive Note : Final rept. 1 Jun 73-30 Jun 76,

Corporate Author : CALIFORNIA UNIV BERKELEY

Personal Author(s) : Rapoport,Henry

PDF Url : ADA116812

Report Date : Sep 1980

Pagination or Media Count : 4

Abstract : New synthetic procedures have been developed which resulted in efficient syntheses of the permethyl analogues of distamycin, an antiviral antibiotic. Methods were also developed for selective acylations among amine, amidine, and guanidine functionalities. None of the compounds synthesized were effective against malaria. (Author)

Descriptors :   *Antimalarials, *Antibiotics, Synthesis(Chemistry), Physiological effects, Efficiency, Deficiencies

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE