Accession Number : ADA117020

Title :   Acute Clinical Malaria (Plasmodium inui) in a Cynomolgus Monkey (Macaca fascicularis).

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD

Personal Author(s) : Stokes,William S ; Donovan,John C ; Montrey,Richard D ; Thompson,William L ; Wannemacher,Robert W , Jr

PDF Url : ADA117020

Report Date : May 1982

Pagination or Media Count : 25

Abstract : Acute clinical malaria caused by Plasmodium inui was diagnosed in an adult female cynomolgus monkey (Macaca fascicularis) 4 years after importation into the United States. Severe clinical disease was attributed to activation of a chronic infection by the stress associated with experimental procedures completed 2 weeks earlier. Clinical findings included severe regenerative anemia, hepatosplenomegaly, weakness, lethargy, weight loss, and anorexia. The infection was treated and successfully eliminated with chloroquine hydrochloride, administered intramuscularly at a dose of 5 mg/kg base given at 0, 6, 24, 48 and 72 hours. Treatment also included a blood transfusion and intensive supportive care. Naturally-occurring malarial infections in nonhuman primates are usually asymptomatic; however, this case was accompanied by severe clinical signs. Laboratory investigators using nonhuman primates should be aware of the potential for activation of latent malarial infections that may result in clinical disease.

Descriptors :   *Plasmodium, *Malaria, Macaca fascicularis, Diagnosis(Medicine), Signs and symptoms, Therapy

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE