Accession Number : ADA117289

Title :   Biochemical Indicators of Infection and Inflammation in Burn Injury.

Descriptive Note : Conference paper,


Personal Author(s) : Powanda,Michael C ; Dubois,John ; Villarreal,Ysidro ; Lieberman,Michael M ; Pruitt,Basil A , Jr

PDF Url : ADA117289

Report Date : 18 Jun 1982

Pagination or Media Count : 15

Abstract : The treatment of severe thermal trauma is very often complicated by infection which occurs readily in such patients (1,2). The loss of the skin barrier and the extensive metabolic and physiologic alterations in burn patients renders detection of infection more difficult and may allow colonization to be mistaken for infection. Three factors have been found in perchloric acid filtrates of whole blood taken from burned-infected rates, two of which appear to be useful indicators of the presence of infection and the third a measure of the presence of inflammation, irrespective of etiology (3,4). The following presents the data that the 398 etameter absorbance factor and the Lambda ex 355, Lambda em 420 fluorescent factor not only denote the presence of infection, but also reflect the severity of infection. Included is the evidence that these two factors require both plasma and cells for their generation as well as the attempts to ascertain which cell population is involved . The data from our initial studies to characterize the substances involved in the generation of these indicators are also presented. (Author)

Descriptors :   *Indicators, *Burns(Injuries), Infectious diseases, Inflammation, Test methods, Blood analysis, Models, Perchloric acid, Rats

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE