Accession Number : ADA117474

Title :   Studies on Butyrylcholinesterase Inhibitors.

Descriptive Note : Conference paper,

Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s) : Wolfe,Alan D. ; Emery,Clarence E. ; Verdier,Jeff S. ; Prichard,Dorothy A.

Report Date : 18 JUN 1982

Pagination or Media Count : 14

Abstract : The ultimate object of the present studies is the elucidation of the structure, function, and physiological significance of the enzyme, butyryl-cholinesterase (BuChE, E.C.3.1.1.8). It occurs in the blood, tissues, ganglia and cytosol of organisms and cells (1,2,3), and its structure (4), substrate, and inhibitor patterns resemble those of acety/cholinesterase (AChE). Both enzymes possess many inhibitors in common, including organo-phosphate (OP) threat agents, but preferential inhibition of either enzyme frequently occurs. Among the compounds which preferentially suppress BuChE in comparison with AChE are those which exert significant neurophar-macological effects, for example, the phenothiazines, tropates, phencyclidines, butyrophenones, imipramines, and curariforms (1,5,6,7,8,9). Phenothiazines, butyrophenones and imipramines are tranquillizers, tropates are spasmodics, and phencyclidines are hallucinogens. BuChE inhibition relative to the pharmacologic or toxic influence of such drugs and threat agents is unknown, despite the overt medical importance these compounds possess. In addition, they possess unusual military significance, since phenothiazines and atropine, in particular, are frequently included in OP antidotal formulations (10,11). (Author)

Descriptors :   *Cholinesterase inhibitors, Organic phosphorus compounds, Antidotes, Detection, Identification, Molecular structure, Dosage, Response(Biology)

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE