Accession Number : ADA117709

Title :   The Etiology and Pathogenesis of Viral Gastroenteritis.

Descriptive Note : Annual progress rept. no. 1, 1 Aug 81-31 Jul 82,

Corporate Author : MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER DEPT OF MEDICINE

Personal Author(s) : Blacklow,Neil R

PDF Url : ADA117709

Report Date : 31 Jul 1982

Pagination or Media Count : 19

Abstract : The purpose of this project is to identify, cultivate, and characterize etiologic agents of viral gastroenteritis of man and to study the pathogenesis of infection in order to provide information necessary to attain the ultimate goals of prevention and cure of this common syndrome. Progress achieved during the current year can be summarized as follows. Monoclonal antibody techniques have been utilized successfully to prepare purified antibodies against Norwalk virus with 5 positive clones now prepared. These monoclonal antibodies are being tested as probes to detect a potential group specific antigen common to the noncytopathic Norwalk-like virus group and to recognize these viruses in nature. In addition, studies are underway to try to cultivate Norwalk virus, using methods that proved successful for the in vitro cultivation of hepatitis A virus and rotavirus.

Descriptors :   *Gastroenteritis, *Virus diseases, Etiology, Pathogenesis, Identification, Humans, Epidemiology, Thailand, Antibodies, Response(Biology)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE