Accession Number : ADA117727

Title :   Effect of Chemical Mutagens on Herpes Virus-Induced Cellular Transformation and Testing for Mutagenesis in Mouse Cells.

Descriptive Note : Final scientific rept. 1 Jun 79-31 May 82,

Corporate Author : BRIGHAM YOUNG UNIV PROVO UTAH DEPT OF MICROBIOLOGY

Personal Author(s) : Johnson,F Brent

PDF Url : ADA117727

Report Date : Jun 1982

Pagination or Media Count : 41

Abstract : Assays which detect quantitative increases of morphological transformation in 3T3 cells were employed to detect transformation by seven temperature sensitive (ts) mutants of herpes simplex type 2 virus (HSV-2). It was determined that all seven mutants caused transformation at the non-permissive temperature. Mutant A8 (293) caused formation of the most foci and appeared to be a more sensitive indicator of transformation in comparative experiments (31 foci per million cells compared to four foci per million cells for ultraviolet-irradiated wild type virus). (Author)

Descriptors :   *Carcinogens, *Mutagens, *Herpes simplex virus, *Hydrazines, *Chemicals, *Methyl hydrazines, Cells(Biology), Morphology(Biology), Transformations, Indicators, Sensitivity, Bioassay, Mutations, Mice

Subject Categories : Medicine and Medical Research
      Toxicology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE