Accession Number : ADA117754

Title :   The Electrophysiologic Mechanisms of Halogenated Alkane Arrhythmogenesis.

Descriptive Note : Annual rept. 1 Sep 80-31 Aug 81,


Personal Author(s) : Strauch,S Mark

PDF Url : ADA117754

Report Date : 28 May 1982

Pagination or Media Count : 32

Abstract : Bromochlorodifluoromethane (1211) has been shown to sensitize the myocardium to the arrhythmogenic effects of various adrenergic amines. The effects of certain physiologic and pharmacologic interventions were tested, including stretching of the tissue fiber, alpha adrenergic interations, cyclic adenosine monophosphate interactions and beta blockade of slow ion channel stimulation. Other studies indicate that 1211 has no apparent direct arrhythmogenic action on the dog heart, but acts only to sensitize the heart to adrenergic amines. Present studies indicate that 1211, like beta adrenergic amines, elevates cellular cyclic adenosine monophosphate levels which, through second messenger action, contributes to the alterations in cardiac membrane properties produced by these agents. (Author)

Descriptors :   *Methanes, *Alkanes, *Halogenated hydrocarbons, Electrophysiology, Physiological effects, Arrhythmia, Heart, Myocardium, Amines, Adenosine phosphates, Cyclic compounds, Interactions, Chlorine compounds, Bromine compounds, Fluorine compounds, Heart rate, Blood pressure

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE