Accession Number : ADA118560

Title :   A Neurobehavioral Study of Rats Using a Model Perfluorinated Acid, NDFDA.

Descriptive Note : Final rept.,

Corporate Author : DISTRICT OF COLUMBIA UNIV WASHINGTON DEPT OF BIOLOGY

Personal Author(s) : Bacon,Inez R

PDF Url : ADA118560

Report Date : 13 Jul 1982

Pagination or Media Count : 20

Abstract : Fischer 344 rats were treated with 10,20, or 30 mg/kg of nonadecafluorodecanoic acid (NDFDA) on day 12 of gestation. Negative controls were given the vehicle (propylene glycol and water; 50:50) and positive controls were given a single ip injection of 500 mg/kg hydroxyurea (diluent, physiological saline). Developmental eruption, eye opening, and growth) and behavior, NDFDA was found to produce increased visuomotor development (visual placing). It is also caused decreased prenatal and postnatal weight gain, delayed cliff avoidance and surface righting, decreased open field rearing, aberrant swimming development and increased auditory startle. The observed effects indicate that NDFDA is a potential toxic neurochemical teratogen. (Author)

Descriptors :   *Fire extinguishing agents, *Organic acids, *Behavior, *Fluorine compounds, *Toxicity, Neurochemistry, Body weight, Rats, Tables(Data)

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE