Accession Number : ADA118812

Title :   Pharmacological Studies on Clostridial Neurotoxins.

Descriptive Note : Annual Rept. No. 1, 1 Nov 81-31 Aug 82

Corporate Author : COLUMBIA UNIV NEW YORK COLL OF PHYSICIANS AND SURGEONS

Personal Author(s) : Simpson,Lance L

PDF Url : ADA118812

Report Date : Aug 1982

Pagination or Media Count : 25

Abstract : Experiments have been done that compare the actions of botulinum toxin type A, tetanus toxin, diphtheria toxin and beta-bungarotoxin on the cholinergic neuromuscular junction. All four toxins bind to tissues without producing adverse effects; each of the toxins has its own unique class of receptors. After tissue binding has occurred, botulinum toxin, tetanus toxin and diphtheria toxin are internalized; this process is antagonized by chloroquine, ammonium chloride and methylamine hydrochloride. Beta-Bungarotoxin is not internalized and is not antagonized by the drugs just listed. Diphtheria toxin acts intracellularly to ADP-ribosylate elongation factor 2. The intracellular actions of botulinum toxin and tetanus toxin have not been determined.

Descriptors :   *Toxins and antitoxins, *Clostridium botulinum, *Bacterial toxins, *Tetanus, *Corynebacterium diphtheriae, Pharmacology, Physiological effects, Proteins, Biosynthesis, Neuromuscular transmission, Neurochemistry

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE