Accession Number : ADA118818

Title :   Artificial Red Cells with Polyhemoglobin Membranes.

Descriptive Note : Final rept. 1 Oct 80-30 Jun 81,

Corporate Author : EXXON RESEARCH AND ENGINEERING CO LINDEN N J

Personal Author(s) : Davis,Thomas A ; Asher,William J ; Quinlan,George T

PDF Url : ADA118818

Report Date : Sep 1981

Pagination or Media Count : 43

Abstract : Artificial red cells were prepared with polyhemoglobin membranes. Red-cell-size microdroplets containing 30% of hemoglobin were held in liquid membrane capsules and treated with glutaraldehyde that cross linked the hemoglobin at the surface of each microdroplet. A water-soluble surfactant was used to eject the cells from the oil and suspend them in saline. The hemoglobin was retained by the artificial red-cell membrane, but biotonometry revealed that it held oxygen more tenaceously after encapsulation. (Author)

Descriptors :   *Blood substitutes, *Hemoglobin, Encapsulation, Erythrocytes, Membranes(Biology), Polymers

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE