Accession Number : ADA119266

Title :   Modeling of Inhalation Administration of Vapors with Capacity Limited Clearance.

Descriptive Note : Interim scientific rept. 30 Jun 81-30 Jun 82,

Corporate Author : MIAMI UNIV FLA SCHOOL OF MEDICINE

Personal Author(s) : Thomas,Vera

PDF Url : ADA119266

Report Date : 12 Jul 1982

Pagination or Media Count : 37

Abstract : Factors, affecting dependence of metabolic clearance of vapors on exposure concentration were investigated. Mathematical solution of multi-compartmental simulation model with one nonlinear elimination pathway was found and programmed for small computer and used for prediction of uptake, distribution and elimination of vapors inhaled under a variety of exposure conditions. (Author)

Descriptors :   *Inhalation, *Toxicity, *Vapors, *Mathematical models, Trichloroethylene, Computerized simulation, Computer programs, Biological absorption, Trachea, Rabbits, Distribution, Metabolism, Interactions, Nitrous oxide

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE