Accession Number : ADA119355
Title : Disposition and Metabolism of Investigational New Drugs.
Descriptive Note : Final rept. 1 Jul 76-31 Dec 79,
Corporate Author : MIDWEST RESEARCH INST KANSAS CITY MO
Personal Author(s) : Shellenberger,Thomas E
PDF Url : ADA119355
Report Date : Sep 1982
Pagination or Media Count : 14
Abstract : During the 39-month experimental period, studies were undertaken to determine absorption, excretion, metabolism and pharmacokinetics in rats, dogs, or rhesus monkeys following single oral doses of 14C-labeled antimalarial chemicals. Samples including blood, excreta, and selected other tissues/organs were collected at various time intervals following dosing and analyzed for 14C content. Selected tissues and excreta were extracted and subjected to thin-layer chromatography (TLC) to determine metabolic profiles.
Descriptors : *Antimalarials, *Quinolines, Metabolism, Pharmacokinetics, Biological absorption, Excretion, Oral dosage, Labeled substances, Tissues(Biology), Rhesus monkeys, Rats, Dogs, Blood analysis
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE