Accession Number : ADA119355

Title :   Disposition and Metabolism of Investigational New Drugs.

Descriptive Note : Final rept. 1 Jul 76-31 Dec 79,

Corporate Author : MIDWEST RESEARCH INST KANSAS CITY MO

Personal Author(s) : Shellenberger,Thomas E

PDF Url : ADA119355

Report Date : Sep 1982

Pagination or Media Count : 14

Abstract : During the 39-month experimental period, studies were undertaken to determine absorption, excretion, metabolism and pharmacokinetics in rats, dogs, or rhesus monkeys following single oral doses of 14C-labeled antimalarial chemicals. Samples including blood, excreta, and selected other tissues/organs were collected at various time intervals following dosing and analyzed for 14C content. Selected tissues and excreta were extracted and subjected to thin-layer chromatography (TLC) to determine metabolic profiles.

Descriptors :   *Antimalarials, *Quinolines, Metabolism, Pharmacokinetics, Biological absorption, Excretion, Oral dosage, Labeled substances, Tissues(Biology), Rhesus monkeys, Rats, Dogs, Blood analysis

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE