Accession Number : ADA119992

Title :   Animal-Model Studies of Radiation-Induced Emesis and Its Control.

Descriptive Note : Interim rept. Jan 75-Jan 81,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX

Personal Author(s) : Cordts,Robert E

PDF Url : ADA119992

Report Date : Aug 1982

Pagination or Media Count : 17

Abstract : This paper reviews work conducted on the subject of radiation-induced emesis. Emesis is considered primarily as a facet of the prodromal syndrome which indicates that a person may have received sufficient radiation to provoke performance decrement of some degree. The subjects were adult male dogs. Four radiation sources were used, and doses ranged between 140 and 800 rad. An orderly progression of work led to the identification of three drugs that, given together 30 minutes prior to cobalt-60 irradiation, raised the emetic threshold about 90%. One experiment, however, suggested that these same drugs may have little benefit when neutron irradiation is used.

Descriptors :   *Radiation effects, *Emesis, *Anatomical models, *Antiemetics, Drugs, Radiation dosage, Dogs, Cobalt, Irradiation, Threshold effects, Humans, Monkeys, Dosage

Subject Categories : Radiobiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE