Accession Number : ADA130068

Title :   Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-38222a, AI3-38223a, AI3-38226a, and AI3-38230a, US Department of Agriculture Proprietary Chemicals.

Descriptive Note : Final rept. Jul 81-Dec 82,


Personal Author(s) : Wade,John V

PDF Url : ADA130068

Report Date : 30 Jun 1983

Pagination or Media Count : 11

Abstract : Preliminary hazard evaluations of AI3-38222a, AI3-38223a, AI2-3226a, and AI3-382230a were performed by means of laboratory animal studies using New Zealand white rabbits, albino Hartley guinea pigs, and Sprague Dawley rats. Chemicals AI3-38222a, AI3-223a, and AI3-38226a produced mild primary skin irritation of the intact skin and the skin surrounding an abrasion. Chemical AI3-3823a did not cause skin irritation. Chemical AI3-38223a was noninjurious to the eyes of rabbits. Chemicals AI3-38222a and AI3-38226a produced mild injury to the cornea. Chemical AI3-38230a produced mild injury to the cornea, and in addition, some injury to the conjunctiva. All chemicals were relatively nontoxic by ingestion and did not cause photoirritation or prove to be skin sensitizers. Ethanol solutions of chemicals AI3-38223a and AI3-38226a demonstrated some skin irritation during photoirritation studies. (Author)

Descriptors :   *Insect repellents, *Toxicity, *Toxic hazards, Test and evaluation, Skin(Anatomy), Irritation, Rabbits, Guinea pigs, Rats, Cornea

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE