Accession Number : ADA130287

Title :   New Techniques and Tools for Clinical Chemistry.

Descriptive Note : Interim technical rept.,

Corporate Author : INDIANA UNIV AT BLOOMINGTON DEPT OF CHEMISTRY

Personal Author(s) : Hieftje,Gary M

PDF Url : ADA130287

Report Date : 01 Jul 1983

Pagination or Media Count : 31

Abstract : In this paper are described and evaluated several new tools of potential use in clinical chemistry. The first, intended to minimize required sample volumes, is a device with which a total sample volume of 1 micro liter can be dispensed in the form of 1000 identical aliquots. Any number of such nanoliter aliquots can be taken if larger samples are needed. The second new tool is one for detecting anions or cations separated by ion chromatography. Unlike conventional conductometric detectors used in ion chromatography, the new system offers potential sensitivities in the sub-micron/L range and useful operating ranges up to 100 mg/L. The third tool is a scheme for background correction in atomic absorption spectrometry; the new technique requires no special auxiliary sources or double-beam optics. Finally, fluorescence time-decay curves and fluorescence lifetimes are shown to be able to overcome the effects of diffusional quenching and scattering resulting from turbidity of solutions in clinical fluorometry.

Descriptors :   *Clinical laboratories, *Chemical analysis, *Laboratory equipment, Chromatography, Atomic spectroscopy, Absorption spectra, Background radiation, Molecular energy levels, Fluorescence, Optics, State of the art

Subject Categories : Test Facilities, Equipment and Methods
      Atomic and Molecular Physics and Spectroscopy

Distribution Statement : APPROVED FOR PUBLIC RELEASE