Accession Number : ADA130601

Title :   The Synthesis and Evaluation of 15-Keto-PGB1 Analogues.

Descriptive Note : Annual technical rept. no. 3, 1 Mar 82-1 Mar 83,

Corporate Author : SAINT JOSEPH'S UNIV PHILADELPHIA PA DEPT OF CHEMISTRY

Personal Author(s) : Nelson,George L

PDF Url : ADA130601

Report Date : 01 Mar 1983

Pagination or Media Count : 29

Abstract : The reaction pathway for the oligomerization of 15-dehydro-PGB1, the PGBx precursor, has been determined to proceed by a Michael addition pathway involving multiple reaction sites. The resultant complexity of such oligomeric mixtures precludes the isolation of individual components from the complex PGBx mixture. As an alternative, procedures were developed to provide less complex mixtures in which oligomers as small as dimers and trimers exhibited activities comparable to PGBx. The dimers were isolated and fully characterized. Blocked 15-dehydro-PGB1 derivatives were also developed. (Author)

Descriptors :   *Synthesis(Chemistry), *Reaction kinetics, *Polymers, *Ketones, *Prostaglandin, Test and evaluation, Molecular weight, Copolymers, Oxidation, Polymerization, Addition reactions, Paths, Protection, Dimers

Subject Categories : Polymer Chemistry
      Plastics

Distribution Statement : APPROVED FOR PUBLIC RELEASE