Accession Number : ADA130661

Title :   Research and Development of Wound Dressing in Maxillofacial Trauma.

Descriptive Note : Annual summary rept. 1 Jul 80-30 Mar 81,

Corporate Author : BIOTEK INC WOBURN MA

Personal Author(s) : Williams,David L ; Kerrigan,James H

PDF Url : ADA130661

Report Date : 15 Apr 1981

Pagination or Media Count : 30

Abstract : Three kilograms of poly-L-((-)lactide have been synthesized for this contract and for Contract No. DAMD 17-80-C-0110. This polymer has a viscosity (R.S.V.) of 1.19 dl.g, a molecular weight (MWw) of 45,700 and a polydispersity of 2.14. Material from a previous contract was used for preliminary experiments. Avitene mat has been obtained from FMC which can be used as a collection element for the non-woven fabric. Povidone-iodine (PVP-I2) from Napp (Co.) is insoluble in methylene chloride. Other grades from BASF are more soluble and also more readily cleared by the kidneys. However, a mixed solvent is required for material preparation. Powders of polymer with lidocaine (HCl), etidocaine (HCl), benzocaine, and PVP-I2 have been prepared using a hammer mill and dry ice. All composites contained 20% drug before and after comminution. Small particle sizes of powder containing the anesthetics released the drug rapidly. A 600-425 micrometer fraction containing 20% etidocaine released 20% of the drug in oue hour, 48% in six hours, and 70% in 24 hours. Modifications of drug loading and drug from (e.g. free base, sulfate) are being considered. PVP-I2 is stable in the powder form, and 10% of the available iodine is found in the diffusion medium after one hour.

Descriptors :   *Dressings, *Wounds and injuries, *Healing, Maxilla, Trauma, Local anesthetics, Antibiotics, Antimicrobial agents, Encapsulation, Powders, Polymers, Fibers, Iodine, Fabrics, Preparation, Release, Collagen, Matrix materials

Subject Categories : Medical Facilities, Equipment and Supplies
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE