Accession Number : ADA130763

Title :   Wound Dressing in Maxillofacial Trauma.

Descriptive Note : Final summary rept. 1 Jan-31 Oct 79,


Personal Author(s) : Williams,David L ; Tenney,Barron W ; Dillon,James J

PDF Url : ADA130763

Report Date : 31 Oct 1979

Pagination or Media Count : 46

Abstract : Biodegradable polymers of poly-L(-)lactide (R.S.V. = 0.3 and 1.3 dl/g), poly-DL-lactide and poly(lactide-co-glycolide) were prepared and blended with drugs for use in wound dressings. Three local anesthetics (procaine, benzocaine, and etidocaine), two antiseptics (iodine and cetylpyridinium chloride, CPC), an anti-inflammatory steroidal drug (hydrocortisone) and epinephrine were studied in non-woven fabirc, film, and powder forms. Drug release was measured as a function of time for 45 different polymer-drug forms. Gelatine (Gelform) and collagen (Acitene) were studied as contact hemostatic agents, imbedded into the polymer surface. Poly-L(-)lactide systems delivered anesthetics in the appropriate time frame. Fiber mats with procaine delivered 9% in one hour and 41% in one day. Films released similarly, and powders faster. Benzocaine and etidocaine were released more slowly. Benzocaine powder released 27% in one hour and 77% in one day, and etidocaine powder released 9% in one hour and 59% in one day. Iodine and epinephrine samples were labile and also quickly released their available drug. The quarternary ammonium antiseptic (CPC) systems were slower to release drug.

Descriptors :   *Dressings, *Polymers, Wounds and injuries, Trauma, Drugs, Release, Biodeterioration, Anesthetics, Fabrics, Films, Powders

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE