Accession Number : ADA131126

Title :   The Mechanism of Blood Function and Production After Injury.

Descriptive Note : Annual progress rept. 1979-1980,

Corporate Author : CALIFORNIA UNIV SAN FRANCISCO

Personal Author(s) : Sheldon,George F

PDF Url : ADA131126

Report Date : Feb 1980

Pagination or Media Count : 23

Abstract : Protein depletion in rats is associated with hemoconcentrated diminution of red cell mass and loss of erythropoiesis. Restoration of nutrition by diet or total parenteral nutrition (TPN) is accompanied by weight gain and restoration of red cell mass. Intravenous repletion of both normal and protein depleted rats, unlike orally refed cohorts, was associated with elevated 2,3 diphosphoglycerate (2,3 DPG) values and anemia. It is postulated that elevated red blood cell 2,3 DPG values in the intravenously refed rats interacted with hemoglobin to enhance oxygen unloading, thereby lowering the hypoxic stimulus for erythropoietin production, and ablating the hypoxic stimulus to the kidney. Because of the lack of a hypoxic stimulus to the kidney, an aregenerative anemia persisted.

Descriptors :   *Blood chemistry, *Wounds and injuries, Rats, Erythropoietins, Bone marrow, Erythropoiesis, Metabolism, Malnutrition, Diet, Anemias, Proteins, Depletion, Feeding, Nutrients, Intravenous bottles, Calorific value, Oxygen consumption, Hemoglobin, Hypoxia, Glycolysis

Subject Categories : Anatomy and Physiology
      Food, Food Service and Nutrition

Distribution Statement : APPROVED FOR PUBLIC RELEASE