Accession Number : ADA131354

Title :   Immunologic Control of Diarrheal Disease due to Enterotoxigenic Escherichia coli: Reactogenicity, Immunogenicity, and Efficacy Studies of Purified Escherichia coli H10407 Type 1 Somatic Pili Vaccine.

Descriptive Note : Annual rept. 1 Feb 80-31 Jan 81,

Corporate Author : MARYLAND UNIV BALTIMORE DIV OF INFECTIOUS DISEASES

Personal Author(s) : Levine,Myron M ; Black,Robert E ; Clements,Mary Lou

PDF Url : ADA131354

Report Date : Sep 1980

Pagination or Media Count : 78

Abstract : Priority tasks in the 1980 contract year were as follows: (1) to develop an immunogenic, non-reactogenic two dose parenteral immunization schedule that would stimulate brisk anti-pili antibody responses without causing adverse reactions. With development of such an immunization procedure, further efficacy challenge studies could proceed. (2) challenge studies to assess the efficacy of the new, non-reactogenic two-dose immunization schedule. (3) more detailed investigation of the circulating O antibody response noted to occur following primary immunization of volunteers with type 1 somatic pilus vaccine. (4) further studies to assess the frequency of occurence of CFA/I, CFA/II and type 1 somatic pili in ETEC pathogens from diverse geographic sources. Development of a Non-Reactogenic Immunogenic Two-Dose Immunization Schedule for Type 1 Somatic Pilus Vaccine Reactogenicity.

Descriptors :   *Vaccines, *Diarrhea, *Escherichia Coli, Immunology, Immunization, Antibodies, Response(Biology), Antigens

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE