Accession Number : ADA132407

Title :   Primary Eye Irritation Potential of the Holston Compounds: Virgin DMSO (Dimethyl Sulfoxide), DMSO Recycle Solvent, and DMSO Evaporator Sludge.

Descriptive Note : Final rept. 10 Feb-30 Mar 83,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Kellner,Thomas P ; White,Craig W ; Fruin,John T

PDF Url : ADA132407

Report Date : Aug 1983

Pagination or Media Count : 38

Abstract : The primary eye irritation potential of the Holston Compounds (Virgin DMSO, DMSO Recycle Solvent, and DMSO Evaporator Sludge) was tested by placing these materials in the conjunctival cul-de-sac of rabbit eyes. The study was conducted in compliance with the Good Laboratory Practice Regulations. All of the Dimethly Sulfoxide compounds tested produced irritation of the conjunctiva early in the study, but the level of severity did not meet the criteria for positive eye irritants.

Descriptors :   *Methyl sulfoxide, *Toxicity, Physiological effects, Eye, Irritation, Rabbits

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE