Accession Number : ADA132408

Title :   The Effectiveness of Aprotinin in Blocking a Shock Factor of Pancreatic Origin from the Pig, Dog, or Monkey.

Descriptive Note : Final rept.,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Traverso,L William

PDF Url : ADA132408

Report Date : Aug 1983

Pagination or Media Count : 14

Abstract : Pancreatic shock factor (PSF) causes profound hypotension when injected into the species of origin (i.e. 'within species', pig PSF into the pig, etc.). Aprotinin, a proteolytic enzyme inhibitor, sucessfully blocked the PSF-induced hypotension 'within species' in the pig but did not alter the hypotension in the dog or monkey. This investigated by infusing PSF from either the pig, dog, or monkey into the other two species ('across species'). PSF was a hypotensive agent 'across species'; aprotinin blocked the hypotensive reaction in each 'across species' combination. Aprotinin is more effective as a blocking agent of PSF when infused 'across' then 'within species'. These species differences of the aprotinin blockade should be considered when designing treatment for shock associated with proteolytic enzymes.

Descriptors :   *Pancreas, *Drugs, *Enzyme inhibitors, Monitoring, Laboratory animals, Hypotension, Peptide hydrolases

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE