Accession Number : ADA132469

Title :   Basic Studies Related to the Development of a Polyvalent Meningococcal Vaccine.

Descriptive Note : Annual rept. Sep-Dec 80,

Corporate Author : PETER BENT BRIGHAM HOSPITAL BOSTON MA

Personal Author(s) : Kass,Edward H ; Griffis,J McLeod

PDF Url : ADA132469

Report Date : Jan 1981

Pagination or Media Count : 7

Abstract : This report summarizes results obtained during the first 4 months of a contract to study two aspects of the development of a polyvalent meningococcal vaccine. The first aspect involves Neisseria meningitidis strain 8021 which produces a capsular polysaccharide with the serologic specificities of both the group Y and group W135 capsular polysaccharides. The objective of this contract was to determine, unambiguously, whether strain 8021 produces an immunochemical mosaic molecule in addition to individual molecules with group Y and group W135 specificities. In pursuit of these objectives, three separate lots of 8021 capsular polysaccharide have been prepared and purified, using the methods developed at the Walter Reed Army Institute of Research for the preparation of meningococcal capsular polysaccharide vaccines. Antisera to prototype group Y and group W135 strains to be used in the preparation of affinity immunosorbent columns have been prepared in rabbits. The second aspect to be studied involved the nature of the human response to the group 29E meningococcal capsular polysaccharide which has been tested as a vaccine in over 100 human volunteers.

Descriptors :   *Vaccines, *Neisseria meningitidis, Serology, Polysaccharides, Humans, Response(Biology), Immunity

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE