Accession Number : ADA132484

Title :   Preparation of HI-6, HGG-12 and Toxogonin.

Descriptive Note : Annual rept. no. 1. 15 Mar 82-15 Mar 83,


Personal Author(s) : Geigel,M A ; Broussard,M M

PDF Url : ADA132484

Report Date : Mar 1983

Pagination or Media Count : 24

Abstract : Published procedures for synthesis of HI-6 result in a difficult-to handle intermediate, and a product contaminated with symmetrical impurities. Because of these comtaminants, purification requires repeated recrystallizations and leads to substantial material losses. We have discovered two methods that result in acceptable quality HI-6. Neither of these methods is optimized, however, and overall yields are low. We currently have 1150 g of 85% pure HI-6, prepared according to Good Manufacturing Practices (GMP). The preparation of Toxogonin is much easier than that of HI-6 because the former is symmetrical. We have 680 g of 99% pure and 400 g of 94% pure Toxogonin prepared according to GMP.

Descriptors :   *Organic compounds, *Synthesis(Chemistry), Purification, Impurities, Salts, Chlorides, Preparation, Formulations(Chemistry)

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE