Accession Number : ADA132656

Title :   Fourteen-Day Subchronic Oral Toxicity Study of 4-Nitrophenyl Methyl (Phenyl) Phosphinate in Male and Female Rats.

Descriptive Note : Final rept. 5 Jan-26 Feb 82,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Lewis,Carolyn M ; Hanes,Martha A ; Waring,Paul P ; Mellick,Paul W ; Marrs,Glen E

PDF Url : ADA132656

Report Date : Sep 1982

Pagination or Media Count : 54

Abstract : A short-term multidose oral toxicity study for 4-nitrophenyl methyl (phenyl) phospinate (MPP) was conducted as a preliminary test for a prolonged 90-day study. Four dose groups of male and female rats (1/2, 1/4, 1/8, and 1/6 of the LD50) were used. Rats were dosed daily by gastric gavage for 14 days. Necropsies and histological examinations were performed on all animals. Urinalysis, standard hematological measurements and an array of serum analyses were performed. In addition, plasma, red blood cell and brain acetylcholinesterase activities were determined. Blood and urine analyses indicated no compound related effects, except slightly depressed red blood cell acetylcholinesterase activity. The only compound related effects found in the histological examinations were gross changes in the digestive system in one or more male rats at the two highest dose levels.

Descriptors :   *Toxicity, *Phosphinates, *Rats, Oral dosage, Nitro radicals, Phenyl radicals, Methyl radicals, Test methods, Long range(Time), Autopsy, Histological techniques, Blood analysis, Urine, Acetylcholinesterase, Digestive system

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE