Accession Number : ADA133793
Title : Development and Validation of a Methodology for Testing Topical Antipruritic Drugs Using Experimentally Induced Pruritus.
Descriptive Note : Master's thesis,
Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
Personal Author(s) : Wilkins,Raymond D
PDF Url : ADA133793
Report Date : Jan 1983
Pagination or Media Count : 84
Abstract : A new double-blind methodology for testing the efficacy of topical antipruritic drugs was evaluated in a series of four experiments. Hair of rose hips was impregnated with histamine and applied to two or three sites on each forearm of volunteers. Pruritus intensity at each site was measured 2 minutes after application of the hair of rose hips (baseline) and 2, 5, 10, 15 and 20 minutes after application of topical study drugs. In experiment 1, the mean pruritus scores were significantly lower for hydrocortisone (0.5%) plus chlorcyclizine (2%) vs. placebo at the 5 and 10 minute time points (p0.017), but there were no significant differences at any time point in experiment 2. There was a statistically significant decrease in the intensity of pruritus in repeat volunteers following treatment with dibucaine (experiment 3) and calamine (experiment 4) as compared to their respective placebo. This effect was not present in volunteers naive to the study. The methodology was thus validated with experienced volunteers but not with volunteers who had not previously participated in the study.
Descriptors : *Drugs, Test and evaluation, Validation, Scoring
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE