Accession Number : ADA133974

Title :   Mutagenic Potential of 4-Nitrophenyl Monochloromethyl (Phenyl) Phosphinate Using the Drosophila melanogaster Sex-Linked Recessive Lethal Test.

Descriptive Note : Final rept. 26 Jul-20 Dec 82,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Powers,Nelson R

PDF Url : ADA133974

Report Date : Aug 1983

Pagination or Media Count : 30

Abstract : 4-Nitrophenyl monochloromethyl (phenyl) phosphinate (TA009) is being considered as a prophylactic agent in anticholinesterase poisoning. It was tested for mutagenic activity using Drosophila melanogaster sex-linked recessive lethal assay. After 72-hour feeding exposures to 0.0100, 0.500, and 0.0075 mM, TA009 appeared non-mutagenic.

Descriptors :   *Phosphinates, *Toxicology, *Mutagens, Phenyl radicals, Nitro radicals, Methyl radicals, Chlorine compounds, Bioassay, Drosophila, Genetics, Damage

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE