Accession Number : ADA134407

Title :   Humoral Control of Regional Blood Flow in Hemorrhagic Shock in Non-Resuscitated and Resuscitated Animals.

Descriptive Note : Annual rept. 1 May-31 Aug 82,

Corporate Author : QUEEN'S MEDICAL CENTER HONOLULU HI CARDIOVASCULAR RESEARCH LAB

Personal Author(s) : McNamara,J Judson

PDF Url : ADA134407

Report Date : Sep 1982

Pagination or Media Count : 97

Abstract : In experiments in rabbits and primates we have: (1) Reaffirmed a prolonged reduction in blood volume and visceral organ flow for periods of at least 18 hours after resuscitation from hemorrhagic shock. (2) Shown that none of the readily identifiable humoral controls of blood pressure or vascular resistance are involved in this flow redistribution (i.e., renin/angiotensin, cathecholamines, thromboxane). (3) Demonstrate improved survival in shocked rabbits treated with ATP-MgC12. (4) Failed to demonstrate any change in mortality in shocked animals subjected to endorphin antagonism with naloxone. (5) Shown no favorable effect of resuscitation with fluorocarbons on survival in rabbits in hemorrhagic shock.

Descriptors :   *Hemorrhagic shock, Blood circulation, Blood volume, Reduction, Blood pressure, Rabbits, Fluorinated hydrocarbons, Angiotensin, Renin, Adenosine phosphates, Magnesium compounds, Chlorides

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE