Accession Number : ADA134408

Title :   The Simulation and Analysis of an Evolutionary Model of Deoxyribonucleic Acid (DNA).

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF SYSTEMS AND LOGISTICS

Personal Author(s) : McNally,Richard E

PDF Url : ADA134408

Report Date : Sep 1983

Pagination or Media Count : 151

Abstract : A Monte Carlo simulation model was developed in order to evaluate model predictions with expectations of the evolutionary hypothesis of nearly neutral point mutations. The beta chain of hemoglobin was chosen as the strand of deoxyribonucleic acid (DNA) to be analyzed due to the extensive characterization of point mutations along the 146 amino acids of the protein chain. The nucleotide sequences of human, rabbit and a hypothetical ancestral hemoglobin were used as a starting point in the simulation. Three models of point mutations were tested. Equiprobable mutation from one nucleotide to any of the remaining three nucleotides composing DNA was one model. The second model incorporated observed first order probability of transition from each nucleotide to the remaining three nucleotides composing DNA using observed probabilities from three independent assessments. The third model was an Ising type model employing a probability of nucleotide change based on the nucleotide composition of the nearest neighbors. Use of these models resulted in evidence to suggest that five methods of simulating the mutations in an evolutionary system produced results that primarily differed in the way in which nulceotide changes resulted in a pattern of amino acid changes.

Descriptors :   *Mathematical models, *Simulation, *Deoxyribonucleic acids, *Monte Carlo method, Evolution(General), Mutations, Predictions, Chains, Hemoglobin, Strands, Amino acids, Proteins, Nucleotides, Sequences, Patterns, Probability, Humans, Rabbits, Theses

Subject Categories : Biochemistry
      Statistics and Probability
      Test Facilities, Equipment and Methods

Distribution Statement : APPROVED FOR PUBLIC RELEASE