Accession Number : ADA135364

Title :   Studies in Boron Chemistry.

Descriptive Note : Final rept. 1 Jul 80-30 Sep 83,

Corporate Author : DUKE UNIV DURHAM NC PAUL M GROSS CHEMICAL LAB

Personal Author(s) : Spielvogel,B F ; McPhail,A T

PDF Url : ADA135364

Report Date : 15 Nov 1983

Pagination or Media Count : 4

Abstract : The exploration of the synthesis and characterization of isoelectronic and isostructural boron analogs of the alpha-amino acids, their precursors, and derivative was continued during this period. The boron analogs are very weak acids with pK1 approximately 8. They exhibit significant anti-arthritic, hypolipidemic, and antitumor activity. The chemistry and activity has been described in publications 1-9 and in patents and patent submissions 1-5.

Descriptors :   *Pharmacology, *Boron, *Analogs, *Synthesis(Chemistry), *Chemical properties, Research management, Bibliographies, Amino acids, Reports, Literature surveys

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE