Accession Number : ADA135364
Title : Studies in Boron Chemistry.
Descriptive Note : Final rept. 1 Jul 80-30 Sep 83,
Corporate Author : DUKE UNIV DURHAM NC PAUL M GROSS CHEMICAL LAB
Personal Author(s) : Spielvogel,B F ; McPhail,A T
PDF Url : ADA135364
Report Date : 15 Nov 1983
Pagination or Media Count : 4
Abstract : The exploration of the synthesis and characterization of isoelectronic and isostructural boron analogs of the alpha-amino acids, their precursors, and derivative was continued during this period. The boron analogs are very weak acids with pK1 approximately 8. They exhibit significant anti-arthritic, hypolipidemic, and antitumor activity. The chemistry and activity has been described in publications 1-9 and in patents and patent submissions 1-5.
Descriptors : *Pharmacology, *Boron, *Analogs, *Synthesis(Chemistry), *Chemical properties, Research management, Bibliographies, Amino acids, Reports, Literature surveys
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE