Accession Number : ADA135430

Title :   Biochemical Basis of Virulence in Epidemic Typhus.

Descriptive Note : Annual rept. Aug 80-Apr 81, Final rept. 1 Feb 79-30 Apr 81,

Corporate Author : UNIVERSITY OF SOUTH ALABAMA MOBILE COLL OF MEDICINE

Personal Author(s) : Winkler,H H

PDF Url : ADA135430

Report Date : Jan 1983

Pagination or Media Count : 32

Abstract : The purpose of the project is to elucidate the biochemical basis of virulence in epidemic typhus. The basic method is a comparison of the E strain and Breninl strain (avirulent and virulent, respectively) of Rickettsia prowazekii in their interaction with the host defense system. Subsequent to the last annual report, work has focused on two areas (1) a study of the ability of virulent and avirulent Rickettsia prowazekii in the cytoplasm of macrophage-like cell lines which employed a fusion technology and (2) the preparation of a manuscript on the macrophage-like cell lines' ability to differentiate the virulent and avirulent typhus rickettsiae.

Descriptors :   *Typhus, *Rickettsia prowazekii, Virulence, Biochemistry, Epidemiology, Strains(Biology), Fatty acids, Interactions, Polymorphonuclear leukocytes, In vitro analysis

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE