Accession Number : ADA135671

Title :   Investigation of Immunoregulatory Alphaglobulin (IRA) in Shock and Trauma.

Descriptive Note : Annual progress rept. 1 Jul 79-30 Jun 80,

Corporate Author : BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA

Personal Author(s) : Mannick,J A

PDF Url : ADA135671

Report Date : Jul 1980

Pagination or Media Count : 29

Abstract : The major accomplishment of the past year of research was the demonstration that a suppressed (by more than 50%) response to PHA was associated with grave prognosis. We further demonstrated that the suppressed PHA response of the lymphocytes of these individuals was caused by the presence of circulating suppressor cells. Nearly all patients with burn injuries of greater than 35% body surface area were found to have circulating low molecular weight immunosuppression factors in the serum. However the presence of such factors could not be related to the survival of the patients. At a dose of approximately 5 mg per animal, a low molecular weight fraction obtained form suppressive serum of burn patients and patients who had undergone surgical trauma was shown to suppress the ability of normal mice to resist infection with Listeria monocytogenes. The same fraction recovered from the serum of normal volunteers had no effect.

Descriptors :   *Shock(Pathology), *Immunity, *Burns(Injuries), *Lymphocytes, Activation, Response(Biology), Patients, Immunosuppression, Immunoglobulins, Trauma

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE