Accession Number : ADA135851

Title :   The Chemical Characteristics of PGBx.

Descriptive Note : Final progress rept.,

Corporate Author : MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF CHEMISTRY

Personal Author(s) : Biemann,K

PDF Url : ADA135851

Report Date : 18 Aug 1983

Pagination or Media Count : 3

Abstract : It was first attempted to separate PGBx, a biologically active material obtained upon alkali treatment of 15-keto-prostaglandin-B1(1), into its components, determine their molecular weight and, finally, molecular structure. When it became clear that PGBx is too complex a mixture, model studies were begun. To investigate the mechanism by which the chemically active moiety in 15-keto-prostaglandin-B1 oligomerizes to PGBx under alkaline conditions, the condensation of 3-ethyl-4-(3'-ketopenten-1-yl) cyclopent-2-enone (2) was investigated.

Descriptors :   *Chemical derivatives, *Chemical properties, Prostaglandin, Molecular structure, Molecular weight, Chemical analysis

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE