Accession Number : ADA136231

Title :   Molecular Mechanisms Involved in Tissue Swelling due to Injury and due to Exposure to Low Temperature and Massive Water and Electrolyte Loss in Diarrheal Disorders,

Corporate Author : PENNSYLVANIA HOSPITAL PHILADELPHIA DEPT OF MOLECULAR BIOLOGY

Personal Author(s) : Ling,G N ; Murphy,R C ; Zodda,D

PDF Url : ADA136231

Report Date : 06 Oct 1980

Pagination or Media Count : 127

Abstract : Swelling of brain as well as a variety of other mouse tissues can be traced to failure to maintain their normal ATP level. More importantly, it was shown that swelling will not occur even after ATP depletion unless the tissues are in an environment containing Na(+) and C1(-) as it is in normal plasma. A quantitative relation has been discovered between the concentration of Na(+) in the surrounding medium and the extent of swelling in brain (and other tissues) whose ATP levels have been reduced by poisons or exposure to low temperature. These findings are in full harmony with a theory of the living cells called the association-induction hypothesis, according to which the Na(+), C1(-), and ATP dependent swelling is due to dissociative effect of salt linkages normally maintaining the cell volume. Other studies confirm the theoretical concepts that certain cells such as the intestinal epithelium conserve body water not due to a postulated lipid bilayers but are due to water existing in the state of polarized multilayers. Such polarized water has reduced solubility for the major osmotically active component of the plasma, Na(+) and C1(-), toxins induce diarrhea as a result of depolarization of water of the intestinal epithelial cells and an increase in the permeability of Na(+) and C1(-) through the barrier of water follows in consequence.

Descriptors :   *Cells(Biology), *Tissues(Biology), *Brain, *Edema, *Molecular biology, *Membranes(Biology), Ions, Sodium, Potassium, Chlorine, Water, Depolarization, Epithelium, Diarrhea, Theory, Mice

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE