Accession Number : ADA136981

Title :   Electrochemical Studies on Minoxidil and Its Determination in Tablets by Differential-Pulse Polarography.

Descriptive Note : Technical rept.,

Corporate Author : UTAH UNIV SALT LAKE CITY DEPT OF CHEMISTRY

Personal Author(s) : Amankwa,L ; Chatten,L G ; Pons,S

PDF Url : ADA136981

Report Date : 16 Jan 1984

Pagination or Media Count : 22

Abstract : A simple differential-pulse polarographic (D.p.p.) method has been developed for the analysis of minoxidil in pharmaceutical dosage forms. The extracting solvent was methanol and the supporting electrolyte was 1.0 N sulphuric acid. An excellent linear relationship was obtained between concentration and current peak height with a correlation coefficient of 0.9999. Good agreement was obtained between results with the d.p.p. method and those by the manufacturer's method of assay. There was no interference by the tablet excipients. In acid solution, a mechanism for reduction at -1.2 V is proposed which involves four electrons transferred as well as dehydration and deamination steps. (Author)

Descriptors :   *Electrochemistry, *Drugs, *Polarography, Coulometers, Voltammetry, Tablets(Chemical), Dosage, Chemical analysis, Extraction, Solvents, Carbinols, Electrolytes, Sulfuric acid, Electric current, Height, Coefficients, Diffusion, Vasodilation

Subject Categories : Pharmacology
      Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE