Accession Number : ADA137228

Title :   Acute Oral Toxicity of DMSO (Dimethyl Sulfoxide) Process Stream Samples in Male and Female Mice.

Descriptive Note : Final rept. 22 Dec 82-18 Jan 83 and 23 Mar-12 Apr 83,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : White,C W ; Rodriguez,J ; Marrs,G E , Jr

PDF Url : ADA137228

Report Date : Dec 1983

Pagination or Media Count : 45

Abstract : The acute toxicity of a single oral dose of the dimethyl sulfoxide stream samples DMSO Evaporator Sludge, DMSO Recycle Solvent, and Virgin DMSO was determined in male and female albino ICR mice. The DMSO Evaporator Sludge solution produced no deaths in male of female mice at a limit dose level of 5.0 ml/kg. The Virgin DMSO solution produced mortalities in one of seven males (14%) and two of seven females (29%) at a limit dose of 5.0 ml/kg. The DMSO Recycle Solvent LD (50) with 95 percent confidence limit was calculated by probit analysis. The DMSO REcycle Solvent LD50 was 4.0 ml/kg in male mice, 95 percent confidence limit (3.2 ml/kg, 5.1 ml/kg) and 2.5 ml/kg in female mice, 95 percent confidence limit (2.2 ml/kg, 2.8 ml/kg).

Descriptors :   *Toxicity, *Methyl sulfoxide, Dosage, Oral intake, Level(Quantity), Lethal dosage, Mice, Sampling

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE