Accession Number : ADA137289

Title :   Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-38225a, AI3-38192a, AI3-38194a, AI3-38599a, and AI3-38427a.

Descriptive Note : Final rept. Jun 81-Nov 83,


Personal Author(s) : Wade,J V ; Harvey,J G , Jr

PDF Url : ADA137289

Report Date : 25 Jan 1984

Pagination or Media Count : 10

Abstract : Chemicals AI3-38192a, AI3-38599a, and AI3-38427a produced no primary skin irritation. Chemicals AI3-38225a and AI3-38194a produced mild irritation of the intact skin and the skin surrounding an abrasion. Chemical AI3-38599a was noninjurious to the eyes of rabbits. Chemical AI3-38192a produced mild injury to the cornea; chemicals AI3-38225a, AI3-38427a, and AI3-38194a produced mild injury to the cornea and, in addition, some injury to the conjunctiva upon application to the eues of rabbits. Chemicals AI3-38225a, AI3-38192a, AI3-38599a, and AI3-38427a did not produce a sensitization reaction. Chemical AI3-383194a produced a slight sensitization reaction in 6 of the 10 guinea pigs tested. All chemicals were relatively nontoxic by ingestion and did not potentiate photoirritation. Recommended that chemicals AI3-38225a, AI3-38192a, AI3-38599a, and AI3-38427a be approved for further testing as candidate insect repellants. Recommended that chemical AI3-38194a be disapproved for further testing due to its sensitizing potential.

Descriptors :   *Insect repellents, *Toxic hazards, Irritation, Eye, Rabbits, Cornea, Guinea pigs, Test and evaluation

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE