Accession Number : ADA137729

Title :   Effect of PFDA on Cardiac Membrane Function.

Descriptive Note : Annual rept. 1 May 82-30 Apr 83,

Corporate Author : WRIGHT STATE UNIV DAYTON OH DEPT OF PHARMACOLOGY

Personal Author(s) : Langley,A E

PDF Url : ADA137729

Report Date : Mar 1983

Pagination or Media Count : 9

Abstract : The in vivo and in vitro heart rates of rats treated with 75 mg/kg PFDA was significantly lower than the in vivo and in vitro heart rates of pair-fed controls 6 to 8 days following treatment. In addition, the rate response of isolated hearts sympathetic nerve stimulation was greater in the PFDA hearts. Beta receptor binding assays were done on homogenates of hearts from PFDA and pair-fed controls 8 days following a single 75 mg/kg dose of PFDA. PFDA treatment resulted in a significant decrease in the number of cardiac beta receptors. Radioimmunoassays of serum levels of T3 and T4 indicate that PFDA produced a significant fall in the levels of both of these thyroid hormones. It is concluded that PFDA produces an alteration of the normal function of cardiac membranes. This effect may be either direct or indirect via changes in thyroid hormonal levels.

Descriptors :   *Thyroid hormones, *Thyroxine, Heart, Membranes(Biology), Heart rate, Physiological effects, Rats, Response(Biology), Blood analysis

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE