Accession Number : ADA138037

Title :   Chemical Ionization Mass Spectrometry: New Methodology.

Descriptive Note : Final rept. 15 Mar 80-14 Sep 83,


Personal Author(s) : Hunt,D F

PDF Url : ADA138037

Report Date : 08 Jan 1984

Pagination or Media Count : 8

Abstract : The goal of this research program was to develop new methodology for the detection and characterization of organic molecules by mass spectrometry. Specific areas addressed included; gas phase ion molecule isotope exchange reactions for counting hydrogen atoms in specific organic structural environments, optimization of tandem mass spectrometry for the direct analysis of complex mixtures of organics, sequence analysis of peptides in mixtures by the combination of collision activated dissociation and tandem mass spectrometry, fragmentation mechanisms of negative ions, and construction of a tandem quadrupole mass spectrometer with improved sensitivity for operation in the FAB ionization mode in the mass range, 1,000 - 2,000 amu. (Author)

Descriptors :   *Mass spectrometry, *Ionization, *Organic compounds, *Molecules, Chemical analysis, Vapor phases, Ions, Isotope exchange, Counting methods, Hydrogen, Atoms, Atomic structure, Mixtures, Peptides, Sequences, Collisions, Dissociation, Fragmentation, Anions, Aromatic hydrocarbons, Carboxylic acids, Sulfur compounds

Subject Categories : Organic Chemistry
      Atomic and Molecular Physics and Spectroscopy

Distribution Statement : APPROVED FOR PUBLIC RELEASE