Accession Number : ADA138073

Title :   System Identification of a Pharmacokinetic Model for Air Force Applications.

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING

Personal Author(s) : Baird,R E

PDF Url : ADA138073

Report Date : Dec 1983

Pagination or Media Count : 132

Abstract : Methods for enhancing the parameter estimation process of pharmacokinetic models were examined and implemented for the Air Force Aerospace Medical Research Laboratory (AFAMRL). The Open Chamber Hexane Model was the primary focus. Optimization algorithms were developed and used to estimate the unknown parameters in order that the model match closely with the experimental data. A sensitivity analysis was then conducted in two parts. First, the sensitivity of the estimated parameters to the error criterion was examined. Second, the use of sensitivity functions in designing future experiments was demonstrated. Finally, recommendations were provided for AFAMRL concerning future attempts in parameter estimation. (Author)

Descriptors :   *Mathematical models, *Pharmacokinetics, Stochastic processes, Optimization, Experimental design, Computer programs, Algorithms, Parameters, Estimates, Sensitivity, Air Force operations, Military applications, Hexanes, Theses

Subject Categories : Pharmacology
      Statistics and Probability

Distribution Statement : APPROVED FOR PUBLIC RELEASE