Accession Number : ADA138252

Title :   HI-6: A Comparative Study of Various Samples,


Personal Author(s) : Clement,J G ; Lockwood,P A ; Thompson,H G

PDF Url : ADA138252

Report Date : Dec 1983

Pagination or Media Count : 18

Abstract : A comparison of the chemical purity, toxicology and efficacy of HI-6 (4-(aminocarbonyl) pyridino)methoxy)methyl)-2(hydroxyimino)methyl)-pyridinium dichloride) obtained from various sources was performed. There were no significant differences between HI-6 obtained from either Israel, Yugoslavia, The Netherlands or Canada regarding their efficacy, when combined with atropine, as an antidote of organophosphate poisoning. HI-6 obtained from Great Britain was significantly more toxic and less efficacious than any of the other HI-6 samples. In addition the results of this study showed that there was no significant difference between HI-6 prepared as a laboratory batch and HI-6 prepared commercially with regards to chemical purity, toxicology or efficacy.

Descriptors :   *Antidotes, Atropine, Poisoning, Organophosphates, Comparison, Sampling, Toxicology, Canada

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE