Accession Number : ADA138676

Title :   Post Traumatic Changes in Serum Fatty Acids and Their Relationship to Organ Failure - Lung and Liver.

Descriptive Note : Rept. no. 3 (Final),

Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s) : Moylan,J A

PDF Url : ADA138676

Report Date : 08 Sep 1982

Pagination or Media Count : 22

Abstract : The study of major organ dysfunction in trauma required an appropriate small animal trauma model as, at the time of the study, the few described in the literature were not reproducible. Furthermore, in order to understand trauma induced biochemical alterations in fatty acid metabolism, a reproducible and accurate measure of plasma free fatty acids was required, since the methods in use were conspicuously nonselective, relatively slow, and often not reproducible. Initial objectives were therefore to develop a rapid and accurate method of determining free fatty acids and to select a small animal model on which trauma studies could be performed. As work progressed, it also became necessary to develop and refine some of the assay procedures.

Descriptors :   *Fatty acids, Metabolism, Lung, Liver, Trauma, Dysfunction, Gas chromatography, Blood serum, Bioassay

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE