Accession Number : ADA138677

Title :   Fatty Acid Metabolism and Pulmonary Insufficiency Studies.

Descriptive Note : Annual progress rept. 1 Oct 78-30 Nov 79,

Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s) : Moylan,J A

PDF Url : ADA138677

Report Date : 22 Oct 1979

Pagination or Media Count : 43

Abstract : A reproducible free fatty acid analysis was carried out with a total of 1407 studies being performed. The results of correlating this to respiratory distress in trauma patients revealed a trend correlating elevated free fatty acid levels with PO2-FiO2 ratios of 1.9, indicating respiratory distress. Patients with normal PO2-FiO2 ratios had relatively normal free fatty acid levels following injury. Animal studies were carried out during the first year showing a reduction of both cytochrome P-450 and mixed function amino oxidase (MFAO) activities following injury. Injury produces an elevation in free fatty acid levels in these animals.

Descriptors :   *Fatty acids, Pulmonary insufficiency, Respiration, Trauma, Patients, Level(Quantity), Metabolism, Correlation

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE